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A Study of Oligoclonal Band Negative Multiple Sclerosis JNNP 60:28-30, Zeman,A.Z.J.,et al, 1996 See this aricle in Pubmed Article Abstract Thirty four patients were identified with apparent OCB negative clinically definite multiple sclerosis.The results of oligoclonal banding proved to have been equivocal in 14 of 34;the clinical diagnosis of multiple sclerosis was questionable in 8 of 34.The remaining 12 patients with"true" OCB negative multiple sclerosis were significantly less disabled than matched OCB positive controls.Re-examination of CSF-serum pairs from six OCB negative patients showed that three remained OCB negative while three showed evidence of intrathecal synthesis of OCBs.OCB negative clinically definitive multiple sclerosis is rare and should be diagnosed with caution;in unequivocal cases it seems to have a relatively benign prognosis.

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(click to filter results - removes previous filter) cerebrospinal fluid cerebrospinal fluid,oligoclonal IgG in misdiagnosis multiple sclerosis multiple sclerosis,diagnosis of multiple sclerosis,differential diagnosis of multiple sclerosis,misdiagnosis

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